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Literature summary for 3.6.5.6 extracted from
- Sulfonamide drugs binding to the colchicine site of tubulin: thermodynamic analysis of the drug-tubulin interactions by isothermal titration calorimetry (2005), J. Med. Chem., 48, 547-555.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Colchicine | enhances GTPase activity of tubulin | Capra hircus |  |
| additional information | N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-fluoro-4-methoxyphenyl)pentafluorobenzenesulfonamide are unable to modulate GTPase activity of tubulin | Capra hircus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Capra hircus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Capra hircus | GDP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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