Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Rattus norvegicus | GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms | GDP + phosphate | - |
? | |
GTP + H2O | Bos taurus | GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms | GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Rattus norvegicus | GDP + phosphate | - |
? | |
GTP + H2O | - |
Bos taurus | GDP + phosphate | - |
? | |
GTP + H2O | GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms | Rattus norvegicus | GDP + phosphate | - |
? | |
GTP + H2O | GTP-binding proteins from the tubulin family, including alpha,beta-tubulin are key components of the cytoskeleton and play central roles in chromosome segregation and cell division. The nucleotide switch of alpha,beta-tubulin is triggered by GTP hydrolysis and regulates microtubule assembly dynamics. Unassembled tubulin-GTP is in the inactive, curved conformation as in tubulin-GDP rings, and is driven into the straight microtubule conformation by the assembly contacts. Binding of the GTP gamma-phosphate only lowers the free energy difference between the curved and straight forms | Bos taurus | GDP + phosphate | - |
? |