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Literature summary for 3.6.5.5 extracted from
- Real-time visualization of dynamin-catalyzed membrane fission and vesicle release (2008), Cell, 135, 1263-1275.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R399A | the mutant displays a severe defect in quaternary structure in solution and on membranes, no detectable membrane tubulation is observed with R399A, nor is R399A capable of mediating membrane fission, R399A is also unable to inhibit fission catalyzed by wild type dynamin | Homo sapiens |
| S45N | the mutant is defective in GTP binding | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | dynamin assembles at the necks of budded vesicles in vivo and functions in membrane fission, dynamin alone is sufficient to catalyze membrane fission and vesiculation from a fluid membrane reservoir | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
| additional information | dynamin assembles at the necks of budded vesicles in vivo and functions in membrane fission, dynamin alone is sufficient to catalyze membrane fission and vesiculation from a fluid membrane reservoir | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dynamin | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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