Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-phosphatidylserine | binds the pleckstrin homology domain of dynamin and enhances its GTPase activity | Mus musculus | |
phosphatidylinositol-4,5-bisphosphate | binds the pleckstrin homology domain of dynamin and enhances its GTPase activity | Mus musculus |
Cloned (Comment) | Organism |
---|---|
His-tagged dynamin I is expressed in Escherichia coli Rosetta2 (DE3) cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide | milnacipran | Mus musculus | |
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine | paroxetine | Mus musculus | |
1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine | mianserin | Mus musculus | |
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile | citalopram | Mus musculus | |
10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine | desipramine | Mus musculus | |
2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-N,N-dimethylethylamine | zotepine | Mus musculus | |
3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine | nortriptyline | Mus musculus | |
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine | chlorpromazine | Mus musculus | |
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine | imipramine | Mus musculus | |
3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine | clomipramine | Mus musculus | |
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one | haloperidol | Mus musculus | |
5H-dibenz[b,f]azepine-5-carboxamide | carbamazepine | Mus musculus | |
fluvoxamine | a noncompetitive inhibitor of dynamin I with respect to GTP and a competitive inhibitor with respect to L-phosphatidylserine | Mus musculus | |
methyl 2-phenyl-2-(2-piperidyl)acetate | methylphenidate | Mus musculus | |
myristyl trimethyl ammonium bromide | standard inhibitor of dynamin I | Mus musculus | |
N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide | tiapride | Mus musculus | |
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine | fluoxetine | Mus musculus | |
N-methyl-9,10-ethanoanthracene-9(10H)-propanamine | maprotiline | Mus musculus | |
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide | sulpiride | Mus musculus | |
sertraline | a mixed type inhibitor with respect to both GTP and L-phosphatidylserine | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0253 | - |
GTP | in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
TALON metal affinity resin column chromatography and MonoQ column chroamtography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | neuronal dynamin I plays a critical role in the recycling of synaptic vesicles, and thus in nervous system function | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dyn I | - |
Mus musculus |
dynamin I GTPase | - |
Mus musculus |
dynamin I guanosine triphosphatase | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0073 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | sertraline | |
0.0147 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | fluvoxamine | |
0.0211 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | N-methyl-9,10-ethanoanthracene-9(10H)-propanamine | |
0.0234 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-piperidine | |
0.0241 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | myristyl trimethyl ammonium bromide | |
0.0299 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 3-(9-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine | |
0.0334 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine | |
0.0372 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine | |
0.0472 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine | |
0.064 | - |
in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | N-(2-diethylaminoethyl)-2-methoxy-5-methylsulfonyl-benzamide | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | methyl 2-phenyl-2-(2-piperidyl)acetate | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 5H-dibenz[b,f]azepine-5-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | (1R,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropane-1-carboxamide | |
0.1 | - |
IC50 above 0.1 mM, in 10 mM Tris-HCl, 10 mM NaCl, 2 mM Mg2+, at 30°C | Mus musculus | 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro[2]benzofuran-5-carbonitrile |