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Literature summary for 3.6.5.5 extracted from

  • Misaka, T.; Murate, M.; Fujimoto, K.; Kubo, Y.
    The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells (2006), Neurosci. Res., 55, 123-133.
    View publication on PubMed

Application

Application Comment Organism
medicine mutations in the dynamin family GTPase OPA1 are reportedly the cause of autosomal dominant optic atrophy Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
wild-type mOPA1 and its mutants are subcloned into the mammalian expression vector pCNX2 for transfection of COS-7 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
D273A OPA1 missense mutation associated with autosomal dominant optic atrophy Mus musculus
E270K OPA1 missense mutation associated with autosomal dominant optic atrophy Mus musculus
K301A loss of function mutation within the G1 GTP-binding domain Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Mus musculus 5743
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
anti-mOPA1 antibodies detect a double band of approximately 90 and 80 kDa Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Mus musculus
-
GDP + phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Mus musculus P58281
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Mus musculus GDP + phosphate
-
ir

Synonyms

Synonyms Comment Organism
dynamin-related GTPase
-
Mus musculus
mOPA1
-
Mus musculus
OPA1
-
Mus musculus