Literature summary for 3.6.5.5 extracted from

Macia, E.; Ehrlich, M.; Massol, R.; Boucrot, E.; Brunner, C.; Kirchhausen, T.
Dynasore, a cell-permeable inhibitor of dynamin (2006), Dev. Cell, 10, 839-850.

Search for more literature for 3.6.5.5

Inhibitors

Inhibitors	Comment	Organism	Structure
dynasore	interferes in vitro with Drp1 (the mitochondrial dynamin) activity of dynamin 2, acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation; interferes in vitro with the GTPase activity of dynamin1, acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation; interferes in vitro with the GTPase activity of dynamin 2, acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Homo sapiens	-	GDP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinantly expressed in insect cells	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Homo sapiens	GDP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Drp1	-	Homo sapiens
dynamin 1	-	Homo sapiens
dynamin 2	-	Homo sapiens
mitochondrial dynamin	-	Homo sapiens

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Release 2023.1 (January 2023)