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Literature summary for 3.6.5.4 extracted from
- Membrane binding of the bacterial signal recognition particle receptor involves two distinct binding sites (2006), J. Cell Biol., 174, 715-724.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the vectors pTD37 and pET22b | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A334W | mutant, exhibits no significant GTP hydrolysis | Escherichia coli |
| G455V | mutant, defective in SRP-FtsY complex formation | Escherichia coli |
| G455W | mutant, exhibits no significant GTP hydrolysis and defective in SRP-FtsY complex formation | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | membrane association of FtsY is stabilized by blocking its GTPase activity | Escherichia coli |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Escherichia coli | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54000 | - |
calculated mass, it migrates in SDS-PAGE as a 90 kDa band | Escherichia coli |
| 400000 | - |
FtsY-SecY translocon complex | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Escherichia coli | - |
GDP + phosphate | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Escherichia coli | GDP + phosphate | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | SRP-FtsY complex | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FtsY | - |
Escherichia coli |
| signal recognition particle receptor | - |
Escherichia coli |
| SR | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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