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Literature summary for 3.6.5.3 extracted from

  • Clementi, N.; Chirkova, A.; Puffer, B.; Micura, R.; Polacek, N.
    Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation (2010), Nat. Chem. Biol., 6, 344-351.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information ribosomes lacking the 23S rRNA and with deletion of SRL region, but not of GAC, inactivate EF-G1 Thermus aquaticus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Thermus aquaticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Thermus aquaticus
-
GDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Thermus aquaticus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Thermus aquaticus GDP + phosphate
-
?
GTP + H2O Base A 2660 is crucial for GTPase activity of EF-G. Reaction rates using reconstituted ribosomes, single turnover measurement, overview Thermus aquaticus GDP + phosphate
-
?

Synonyms

Synonyms Comment Organism
EF-G GTPase
-
Thermus aquaticus
EF-G1
-
Thermus aquaticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Thermus aquaticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Thermus aquaticus

General Information

General Information Comment Organism
physiological function the EF-G GTPase mediates the movement of the tRNA2-mRNA complex during translation Thermus aquaticus