Literature summary for 3.6.5.3 extracted from

Daviter, T.; Wieden, H.J.; Rodnina, M.V.
Essential role of histidine 84 in elongation factor Tu for the chemical step of GTP hydrolysis on the ribosome (2003), J. Mol. Biol., 332, 689-699.

Search for more literature for 3.6.5.3

Protein Variants

Protein Variants	Comment	Organism
H84A	reduces the rate constant of GTP hydrolysis more than 1000000fold, the preceding steps of ternary complex binding to the ribosome, codon recognition and the GTPase activation step are affected only slightly. The catalytic role of His84 in elongation factor Tu is to stabilize the transition state of GTP hydrolysis by hydrogen bonding to the attacking water molecule or, possibly, the gamma-phosphate group of GTP	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	the catalytic role of His84 in elongation factor Tu is to stabilize the transition state of GTP hydrolysis by hydrogen bonding to the attacking water molecule or, possibly, the gamma-phosphate group of GTP	Escherichia coli	GDP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
EF-Tu	-	Escherichia coli
elongation factor Tu	-	Escherichia coli

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Release 2023.1 (January 2023)