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Literature summary for 3.6.5.3 extracted from

  • Antoun, A.; Pavlov, M.Y.; Andersson, K.; Tenson, T.; Ehrenberg, M.
    The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis (2003), EMBO J., 22, 5593-5601.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Escherichia coli IF2 in complex with GTP, but not GDP promotes fast association of ribosomal subunits during initiation. IF2 promotes fast formation of the first peptide bond in the presence of GTP, but not GDP. GTP form of IF2 accelerates formation of the 70S ribosome from subunits and GTP hydrolysis accelerates release of IF2 from the 70S ribosome GDP + phosphate
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O IF2 in complex with GTP, but not GDP promotes fast association of ribosomal subunits during initiation. IF2 promotes fast formation of the first peptide bond in the presence of GTP, but not GDP. GTP form of IF2 accelerates formation of the 70S ribosome from subunits and GTP hydrolysis accelerates release of IF2 from the 70S ribosome Escherichia coli GDP + phosphate
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?

Synonyms

Synonyms Comment Organism
IF2
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Escherichia coli
initiation factor 2
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Escherichia coli