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Literature summary for 3.6.5.2 extracted from

  • Ji, P.; Jayapal, S.R.; Lodish, H.F.
    Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2 (2008), Nat. Cell Biol., 10, 314-321.
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
additional information mDia2 is a downstream effector of the Rho GTPases Rac1 and Rac2, Rac1 and Rac2 bind to mDia2 GBD in a GTP-dependent manner Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
G12V constitutively active Rac mutant Mus musculus
T17N dominant negative Rac mutant Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
NSC23766 Rac-specific inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Rac GTPases play an important role in enucleation of mammalian erythroblasts ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose 4B bead chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
erythroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanosine 5'-O-(3-thiotriphosphate) + H2O
-
 Mus musculus guanosine 5'-O-diphosphate + thiophosphate
-
 ?
additional information Rac GTPases play an important role in enucleation of mammalian erythroblasts Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Rac GTPase
-
 Mus musculus
Rac1 isoform Mus musculus
Rac2 isoform Mus musculus