Literature summary for 3.6.5.2 extracted from

Osanai, K.; Oikawa, R.; Higuchi, J.; Kobayashi, M.; Tsuchihara, K.; Iguchi, M.; Jongsu, H.; Toga, H.; Voelker, D.R.
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice (2008), Am. J. Pathol., 173, 1265-1274.

Search for more literature for 3.6.5.2

Protein Variants

Protein Variants	Comment	Organism
additional information	the chocolate mutation is attributed to a G146T transversion in the conserved GTP/GDP-interacting domain of Rab38, recombinant Rab38chocolate proteins retain GTP-binding activity but fail to undergo prenyl modification, the genetic abnormality of Rab38 affects multiple lysosome-related organelles, resulting in lung disease in addition to oculocutaneous albinism	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	Rab38 displays highest expression levels in the lung	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Mus musculus	GDP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Rab38	-	Mus musculus
small GTPase	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)