Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Galphaq | - |
Homo sapiens |
heterotrimeric G-protein | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | Rho guanine nucleotide exchange factor p63RhoGEF619 relocates to the plasma membrane upon activation of Galphaq coupled GPCRs, resembling the well-known activation mechanism of Rho guanine nucleotide exchange factors (RhoGEFs) activated by Galpha12/13. Synthetic recruitment of p63RhoGEF619 to the plasma membrane increases RhoGEF activity towards GTPase RhoA, but full activation requires allosteric activation via Galphaq, overview. Dual role for heterotrimeric G-protein Galphaq in RhoGEF activation, as it both recruits and allosterically activates cytosolic ARHGEF25 gene encoding three RhoGEF isoforms. Activation of the heterotrimeric G-protein Galphaq relieves the DH domain of p63RhoGEF from its autoinhibited state by allosteric interaction with the PH domain | Homo sapiens |