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Literature summary for 3.6.5.1 extracted from

  • Leal, J.I.; Villaseca, S.; Beyer, A.; Toro-Tapia, G.; Torrejon, M.
    Ric-8A, a GEF for heterotrimeric G-proteins, controls cranial neural crest cell polarity during migration (2018), Mech. Dev., 154, 170-178 .
    View publication on PubMed
Search for more literature for 3.6.5.1

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the levels of Ric-8A are critical during migration and affect the localization of polarity markers and the subcellular localization of GTPase activity Xenopus tropicalis
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Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Xenopus tropicalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Xenopus tropicalis
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 GDP + phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Xenopus tropicalis
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Xenopus tropicalis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
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 Xenopus tropicalis GDP + phosphate
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 ?

Synonyms

Synonyms Comment Organism
GTPase
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 Xenopus tropicalis
heterotrimeric G-protein
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 Xenopus tropicalis

General Information

General Information Comment Organism
metabolism Ric-8A controls cell polarization during migration probably through Galpha subunit regulation. Ric-8A by its two function as GEF and chaperone may regulate cell polarity by regulating the localization of proteins, such as Galpha-GDP, GPR1/GPR2 and Lin-5, during asymmetric cell division. Therefore in the context of migration it may also interact with a Galpha subunit, and its downstream effectors regulating aPKC and Par3 localization, then under Ric-8A morphant condition, the localization of these proteins is abnormal. Because GTPases regulate each other, any misregulation in one can result in abnormal regulation in the others Xenopus tropicalis
physiological function heterotrimeric G proteins control cell migration in a variety of cellular types, also during embryogenesis. Four of the five Galpha subunit family members (Galpha12/13, Galphai/o, Galpha/11, and Galphas) are related to migration, activating different signaling cascades and promoting actin cytoskeleton reorganization through the regulation of small GTPase family proteins. The canonical cycle of heterotrimeric G protein signaling begins when a ligand binds to its receptor, which acts as a GEF and induces the activation of Galpha subunits and release from Gbetagamma by the exchange of GDP by GTP. In addition, some GEFs are ligand-independent, such as Ric-8, which accelerates the exchange of GDP for GTP on the Galpha subunit, thereby maintaining an active signaling state. The levels of Ric-8A are critical during migration and affect the localization of polarity markers and the subcellular localization of GTPase activity, suggesting that Ric-8A, probably through heterotrimeric G-protein signaling, regulates cell polarity during CNC migration, overview Xenopus tropicalis