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Literature summary for 3.6.5.1 extracted from

  • Orth, J.H.; Preuss, I.; Fester, I.; Schlosser, A.; Wilson, B.A.; Aktories, K.
    Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation (2009), Proc. Natl. Acad. Sci. USA, 106, 7179-7184.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Pasteurella multocida toxin
-
Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q209E increase of enzyme activity Mus musculus
Q209L increase of enzyme activity Mus musculus
R183C increase of enzyme activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Pasteurella multocida toxin deamidates glutamine-205 of G alphaI2 to glutamic acid, inhibits intrinsic GTPase activity, causes persistent activation of the G protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
MEF cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O assay at pH 7.5, 15 mM MgCl Homo sapiens GDP + phosphate
-
?

Synonyms

Synonyms Comment Organism
G alpha i2
-
Homo sapiens
G alpha q
-
Mus musculus
heterotrimeric G protein
-
Mus musculus
heterotrimeric G protein
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens