Cloned (Comment) | Organism |
---|---|
- |
Methanococcus voltae |
Crystallization (Comment) | Organism |
---|---|
crystallization of a hexameric form of a truncated Methanococcus voltae RadA protein devoid of its small N-terminal domain, crystals are grown by the hanging drop method The RadA hexamers further assemble into two-ringed assemblies | Methanococcus voltae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanococcus voltae | O73948 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
RadA | - |
Methanococcus voltae |
General Information | Comment | Organism |
---|---|---|
physiological function | archaeal RadA proteins are close homologues of eukaryal Rad51 and DMC1 proteins and are remote homologues of bacterial RecA proteins. For the repair of double-stranded breaks in DNA, these recombinases promote a pivotal strand-exchange reaction between homologous single-stranded and double-stranded DNA substrates. This DNA-repair function also plays a key role in the resistance of cancer cells to chemotherapy and radiotherapy and in the resistance of bacterial cells to antibiotics | Methanococcus voltae |