Literature summary for 3.6.4.B1 extracted from

Bernasconi, P.; Cappelletti, C.; Navone, F.; Nessi, V.; Baggi, F.; Vernos, I.; Romaggi, S.; Confalonieri, P.; Mora, M.; Morandi, L.; Mantegazza, R.
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies (2008), J. Neuropathol. Exp. Neurol., 67, 624-632.

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Application

Application	Comment	Organism
medicine	in muscles of patients with idiopathic inflammatory myopathies, KIF4-positive inflammatory cells are found. In polymyositis and inclusion body myositis, KIF4-positive cells are mainly located around individual muscle fibers, whereas in dermamyositis, KIF4-positive cells are also near blood vessels. KIF4-positive cells are not specific to any immune lineage. In peripheral blood lymphocytes stimulated with mitogens, KIF4 expression is upregulated, and the protein is localized in the cytoplasm associated with lysosome-associated protein 1+ and perforin+ lysosomal vesicles	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	in peripheral blood lymphocytes stimulated with mitogens, KIF4 expression is upregulated, and the protein is localized in the cytoplasm associated with lysosome-associated protein 1+ and perforin+ lysosomal vesicles	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with idiopathic inflammatory myopathies	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lymphocyte	in peripheral blood lymphocytes stimulated with mitogens, KIF4 expression is upregulated, and the protein is localized in the cytoplasm associated with lysosome-associated protein 1+ and perforin+ lysosomal vesicles	Homo sapiens	-
muscle	in muscles of patients with idiopathic inflammatory myopathies, KIF4-positive inflammatory cells are found. In polymyositis and inclusion body myositis, KIF4-positive cells are mainly located around individual muscle fibers, whereas in dermamyositis, KIF4-positive cells are also near blood vessels. KIF4-positive cells are not specific to any immune lineage	Homo sapiens	-

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Release 2023.1 (January 2023)