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Literature summary for 3.6.4.7 extracted from

  • Saffert, P.; Enenkel, C.; Wendler, P.
    Structure and function of p97 and Pex1/6 type II AAA+ complexes (2017), Front. Mol. Biosci., 4, 33 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.7

Activating Compound

Activating Compound Comment Organism Structure
Syt1 the cytoplasmic fragment of synaptotagmin Syt1 can substantially increase the basal ATPase activity by approximately 4fold Caenorhabditis elegans

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Saccharomyces cerevisiae
Mg2+ dependent on Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ?
ATP + H2O Caenorhabditis elegans
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ?
ATP + H2O
-
 Caenorhabditis elegans ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
heterohexamer Pex1 and Pex6 forma heterohexamer composed of a trimer of Pex1/6 dimers Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Cdc48
-
 Caenorhabditis elegans
p97/VCP
-
 Caenorhabditis elegans
peroxin
-
 Saccharomyces cerevisiae
PEX1/6
-
 Saccharomyces cerevisiae
Pex1/6 type II AAA+ complex
-
 Saccharomyces cerevisiae
Pex1/Pex6 complex
-
 Saccharomyces cerevisiae
valosin-containing protein
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction mutations in Pex1 and Pex6 cause peroxisome biogenesis disorders Saccharomyces cerevisiae
physiological function the enzyme plays a role in many processes, including endoplasmic reticulum-associated protein degradation Caenorhabditis elegans
physiological function the Pex1/Pex6 complex dislocates and recycles the transport receptor Pex5 from the peroxisomal membrane during peroxisomal protein import Saccharomyces cerevisiae