Literature summary for 3.6.4.7 extracted from

Goto-Yamada, S.; Mano, S.; Nakamori, C.; Kondo, M.; Yamawaki, R.; Kato, A.; Nishimura, M.
Chaperone and protease functions of LON protease 2 modulate the peroxisomal transition and degradation with autophagy (2014), Plant Cell Physiol., 55, 482-496.

Search for more literature for 3.6.4.7

Cloned(Commentary)

Cloned (Comment)	Organism
gene At5g47040, DNA and amino acid sequence determination and analysis, isozyme LON2 is encoded by gene aberrant peroxisome morphology 10, apem10	Arabidopsis thaliana

Protein Variants

Protein Variants	Comment	Organism
Q144stop	naturally occuring mutation, gene At5g47040 expression is sufficient to rescue the apem10 phenotype, overview	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Arabidopsis thaliana	5777	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	O64948	Lon protease homolog 2, peroxisomal; gene apem10	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arabidopsis thaliana	-

Synonyms

Synonyms	Comment	Organism
APEM10	-	Arabidopsis thaliana
LON protease 2	-	Arabidopsis thaliana
lon2	-	Arabidopsis thaliana
peroxisomal protease LON2	-	Arabidopsis thaliana

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
malfunction	the Arabidopsis apem10 mutant displays accelerated peroxisome degradation and a dramatically reduces number of peroxisomes. LON2 deficiency causes enhanced peroxisome degradation by autophagy, and peroxisomal proteins accumulates in the cytosol due to a decrease in the number of peroxisomes. The loss of function of LON2 leads to accelerated autophagy, accumulation of electron-dense inclusions in the peroxisome matrix and a delay in the elimination of glyoxysomal enzymes during post-germinative growth. apem10 phenotype, overview	Arabidopsis thaliana
metabolism	the enzyme is involved in LON2- and autophagy-dependent degradation pathways during the functional transition of peroxisomes, two hypothetical mechanisms proposed for the functional transition of glyoxysomes to leaf peroxisomes, modeling	Arabidopsis thaliana
physiological function	LON2 is involved in the peroxisomal functional transition and basal quality control of peroxisomes. Chaperone and protease functions of LON protease 2 modulate the peroxisomal transition and degradation with autophagy. Proteolytic consequence of LON2 for the degradation of peroxisomal proteins, unnecessary proteins are eliminated by LON2- and autophagy-dependent degradation pathways during the functional transition of peroxisomes. LON2 plays dual roles as an ATP-dependent protease and a chaperone. The chaperone domain of LON2 is essential for the suppression of autophagy, whereas its peptidase domain interferes with this chaperone function, indicating that intramolecular modulation between the proteolysis and chaperone functions of LON2 regulates degradation of peroxisomes by autophagy	Arabidopsis thaliana

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Release 2023.1 (January 2023)