Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.4.7 extracted from

  • Nashiro, C.; Kashiwagi, A.; Matsuzaki, T.; Tamura, S.; Fujiki, Y.
    Recruiting mechanism of the AAA peroxins, Pex1p and Pex6p, to Pex26p on the peroxisomal membrane (2011), Traffic, 12, 774-788.
    View publication on PubMed
Search for more literature for 3.6.4.7

Protein Variants

Protein Variants Comment Organism
D662N Walker-motif mutant: mutant shows a lower level of targeting to EGFP-Pex26p as compared to wild-type Homo sapiens
D803N Walker-motif mutant: mutant is transported to peroxisomes by EGFP-Pex26p to the same level as wild-type Homo sapiens
D940N Walker-motif mutant: mutant shows a normal or slightly increased level of targeting to EGFP-Pex26p as compared to wild-type Homo sapiens
K476E Walker-motif mutant: mutant shows a lower level of targeting to EGFP-Pex26p as compared to wild-type Homo sapiens
K605E Walker-motif mutant: mutant are significantly reduced in translocation to EGFP-Pex26p as compared to wild-type Homo sapiens
K750E Walker-motif mutant: mutant shows a lower level of targeting to EGFP-Pex26p as compared to wild-type Homo sapiens
K887E Walker-motif mutant: mutant are significantly reduced in translocation to EGFP-Pex26p as compared to wild-type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome Pex1p is targeted to peroxisomes in a manner dependent on ATP hydrolysis. Transport of Pex1p and Pex6p is temperature-dependent Homo sapiens 5777
-
peroxisome Pex6p targeting to peroxisomes requires ATP but not its hydrolysis. Transport of Pex1p and Pex6p is temperature-dependent Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens in vitro binding assays with GST-fused Pex26p show that Pex1p and Pex6p bind to Pex26p in a manner dependent on ATP binding but not ATP hydrolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
additional information in vitro binding assays with GST-fused Pex26p show that Pex1p and Pex6p bind to Pex26p in a manner dependent on ATP binding but not ATP hydrolysis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Pex1p
-
 Homo sapiens
Pex6p
-
 Homo sapiens