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Literature summary for 3.6.4.6 extracted from

  • Schoeneberg, J.; Pavlin, M.R.; Yan, S.; Righini, M.; Lee, I.H.; Carlson, L.A.; Bahrami, A.H.; Goldman, D.H.; Ren, X.; Hummer, G.; Bustamante, C.; Hurley, J.H.
    ATP-dependent force generation and membrane scission by ESCRT-III and Vps4 (2018), Science, 362, 1423-1428 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
E233Q inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap Q Sepharose column chromatography and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Vps4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is intimately associated with the ESCRT machinery and is essential for the membrane scission cycle. The enzyme is recruited to scission sites by Vps2. By recycling Vps2, the enzyme promotes Snf7 polymerization. Thus, the enzyme is critical for the recycling of ESCRT-III and the replenishment of the soluble cytoplasmic pool Homo sapiens