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Literature summary for 3.6.4.13 extracted from

  • Bennett, A.H.; ODonohue, M.F.; Gundry, S.R.; Chan, A.T.; Widrick, J.; Draper, I.; Chakraborty, A.; Zhou, Y.; Zon, L.I.; Gleizes, P.E.; Beggs, A.H.; Gupta, V.A.
    RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes (2018), PLoS Genet., 14, e1007226 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.13

Protein Variants

Protein Variants Comment Organism
additional information ddx27 mutant zebrafish show skeletal muscle abnormalities. Overexpression of human DDX27 mRNA results in a significant decrease in mutant zebrafish phenotype Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
 Danio rerio 5840
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Danio rerio
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio Q6DRN0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Danio rerio
-
larva
-
 Danio rerio
-
skeletal muscle
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Danio rerio ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
DDX27
-
 Danio rerio
DEAD-box RNA helicase
-
 Danio rerio
RNA helicase DDX27
-
 Danio rerio

General Information

General Information Comment Organism
malfunction ddx27 mutant zebrafish show skeletal muscle abnormalities and growth defects, but without significant expression changes in muscle progenitor cell markers, pax3 and pax7 during the embryonic stage. Significant downregulation of both pax7a and b is observed during the larval stage in ddx27 mutant zebrafish, and reduced Pax7-positive cell proliferation and impaired regeneration in Ddx27 deficiency. Concurrently, with a downregulation of pax3 and pax7a/b, high expression of myoD, myf5 and desmin in mutant muscles is observed suggesting a premature activation of the myogenic program in Ddx27 deficiency. Skeletal muscle hypotrophy and precocious differentiation occur in Ddx27 deficiency, and reduced contractile strength and prolonged muscle relaxation in Ddx27-deficient skeletal muscles. Ddx27 deficiency phenotype, detailed overview. Ddx27 deficiency perturbs the translation of specific subset of mRNA repertoires Danio rerio
metabolism role of RNA helicase Ddx27 in skeletal muscle homeostasis Danio rerio
physiological function Ddx27 plays a pivotal role in skeletal muscle regeneration Danio rerio