Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.4.13 extracted from

  • Salman-Dilgimen, A.; Hardy, P.; Dresser, A.; Chaconas, G.
    HrpA, a Deah-Box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete (2011), PLoS ONE, 6, e22168.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
-
-
-

Synonyms

Synonyms Comment Organism
HRpA
-
Borreliella burgdorferi

General Information

General Information Comment Organism
malfunction disruption of the hrpA gene results in a complete loss in the ability of the spirochetes to infect mice by needle inoculation. Protein expression analysis show a total of 187 differentially regulated proteins in an hrpA background: 90 downregulated and 97 upregulated. 42 of the 90 downregulated and 65 of the 97 upregulated proteins are not regulated under any conditions by the previously reported regulators in Borrelia burgdorferi (bosR, rrp2, rpoN, rpoS or rrp1) Borreliella burgdorferi