Protein Variants | Comment | Organism |
---|---|---|
Y593F | expression of the mutant enzyme in SW620 cells leads to Snail repression, E-cadherin upregulation and vimentin repression | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of p68 RNA helicase at Y593 upregulates transcription of the Snail1 gene | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SW-480 cell | - |
Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
p68 RNA helicase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphorylation of p68 RNA helicase at Y593 upregulates transcription of the Snail1 gene. The phosphorylated p68 activates transcription of the Snail1 gene by promoting histone deacetylase dissociation from the Snail1 promoter. p68 interacts with the nuclear remodeling and deacetylation complex MBD3:Mi-2/NuRD. The DEAD-box RNA unwindase could potentially regulate gene expression by functioning as a protein displacer to modulate proteinprotein interactions at the chromatin-remodeling complex | Homo sapiens |