Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP-gamma-S | 5.4 mM, about 50% of the original helicase activity is inhibited, competitive inhibitor | Hepacivirus C | |
additional information | several extracts of marine organisms exhibit different inhibitory effects on the RNA and DNA helicase activities of HCV NS3 | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Hepacivirus C |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
development of continuous fluorescence assay based on fluorescence resonance energy transfer for the monitoring of RNA helicase activity in vitro. This assay will be useful for monitoring the detailed kinetics of RNA unwinding mechanisms and screening RNA helicase inhibitors at high throughput | Hepacivirus C |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | unwinding of dsRNA | Hepacivirus C | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCV NS3 helicase | - |
Hepacivirus C |