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Literature summary for 3.6.4.13 extracted from

  • Shuman S.
    Vaccinia virus RNA helicase. Directionality and substrate specificity (1993), J. Biol. Chem., 268, 11798-11802.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
single-strandede DNA stimulates Vaccinia virus

Metals/Ions

Metals/Ions Comment Organism Structure
NaCl stimulates at 300-500 mM Vaccinia virus

Organism

Organism UniProt Comment Textmining
Vaccinia virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O unwinds duplex RNA exclusively in a 3' to 5' direction with respect to the strand to which the enzyme is bound and along which it is presumed to translocate. NTP hydrolysis by RNA bound NPH-II1 drives processive translocation of the protein in a 3’ to 5‘ direction along the RNA strand Vaccinia virus ADP + phosphate
-
?
additional information the enzyme is unable to unwind duplex DNA Vaccinia virus ?
-
?

Synonyms

Synonyms Comment Organism
NPH-II
-
Vaccinia virus