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Literature summary for 3.6.4.10 extracted from

  • Yokoyama, Y.; Ohtaki, A.; Jantan, I.; Yohda, M.; Nakamoto, H.
    Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity (2015), J. Biochem., 157, 161-168 .
    View publication on PubMed
Search for more literature for 3.6.4.10

Activating Compound

Activating Compound Comment Organism Structure
goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 (1.56fold at 0.04 mg/ml) Synechococcus elongatus
goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 (1.76fold at 0.04 mg/ml) Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
goniothalamin inhibits the chaperone activity of the enzyme Hsp90 Schizosaccharomyces pombe
goniothalamin inhibits the chaperone activity of the enzyme Hsp90 Synechococcus elongatus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.43
-
 ATP in the absence goniothalamin, at pH 8.0 and 37°C Synechococcus elongatus
0.51
-
 ATP in the absence goniothalamin, at pH 8.0 and 37°C Schizosaccharomyces pombe
0.66
-
 ATP in the presence of 0.04 mg/ml goniothalamin, at pH 8.0 and 37°C Synechococcus elongatus
0.73
-
 ATP in the presence of 0.04 mg/ml goniothalamin, at pH 8.0 and 37°C Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Schizosaccharomyces pombe
-
 ADP + phosphate
-
 ?
ATP + H2O Synechococcus elongatus
-
 ADP + phosphate
-
 ?
ATP + H2O Synechococcus elongatus PCC 7942
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-
Synechococcus elongatus
-
-
-
Synechococcus elongatus PCC 7942
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Schizosaccharomyces pombe ADP + phosphate
-
 ?
ATP + H2O
-
 Synechococcus elongatus ADP + phosphate
-
 ?
ATP + H2O
-
 Synechococcus elongatus PCC 7942 ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 73000, SDS-PAGE Synechococcus elongatus

Synonyms

Synonyms Comment Organism
90-kDa heat shock protein
-
 Schizosaccharomyces pombe
90-kDa heat shock protein
-
 Synechococcus elongatus
Hsp90
-
 Schizosaccharomyces pombe
Hsp90
-
 Synechococcus elongatus
HtpG
-
 Synechococcus elongatus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0195
-
 ATP in the absence goniothalamin, at pH 8.0 and 37°C Schizosaccharomyces pombe
0.0253
-
 ATP in the absence goniothalamin, at pH 8.0 and 37°C Synechococcus elongatus
0.0408
-
 ATP in the presence of 0.04 mg/ml goniothalamin, at pH 8.0 and 37°C Synechococcus elongatus
0.0438
-
 ATP in the presence of 0.04 mg/ml goniothalamin, at pH 8.0 and 37°C Schizosaccharomyces pombe