Activating Compound | Comment | Organism | Structure |
---|---|---|---|
15-deoxyspergualin | stimulates the ATPase activity of mammalian and yeast cytosolic Hsc70 from 20 to 40%, no effect on HSC70 BiP and DnaJ-stimulated Hsc70 ATPase activity | Saccharomyces cerevisiae | |
15-deoxyspergualin | stimulates the ATPase activity of mammalian and yeast cytosolic Hsc70 from 20 to 40%, no effect on HSC70 BiP and DnaJ-stimulated Hsc70 ATPase activity | Bos taurus | |
DnaJ | - |
Rattus norvegicus | |
DnaJ | - |
Saccharomyces cerevisiae | |
DnaJ | - |
Bos taurus |
Application | Comment | Organism |
---|---|---|
medicine | development of a potent cytostatic anti-tumor and immunosuppressive agent, 15-deoxyspergualin, a synthetic analogue of the antibiotic spergualin, to prevent rejection in kidney transplant recipients | Saccharomyces cerevisiae |
medicine | development of a potent cytostatic anti-tumor and immunosuppressive agent, 15-deoxyspergualin, a synthetic analogue of the antibiotic spergualin, to prevent rejection in kidney transplant recipients | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
cytosol | - |
Bos taurus | 5829 | - |
endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
endoplasmic reticulum | - |
Bos taurus | 5783 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
gel filtration | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Rattus norvegicus | - |
ADP + phosphate | - |
? | |
ATP + H2O | Saccharomyces cerevisiae | - |
ADP + phosphate | - |
? | |
ATP + H2O | Bos taurus | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
rat | - |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Rattus norvegicus | |
ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Saccharomyces cerevisiae | |
ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Rattus norvegicus | ADP + phosphate | - |
? | |
ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
? | |
ATP + H2O | - |
Bos taurus | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eukaryotic Hsc70 ATPase | - |
Saccharomyces cerevisiae |
eukaryotic Hsc70 ATPase | - |
Bos taurus |