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Literature summary for 3.6.4.10 extracted from

  • Hiromura, M.; Yano, M.; Mori, H.; Inoue, M.; Kido, H.
    Intrinsic ADP-ATP exchange activity is a novel function of the molecular chaperone, Hsp70 (1998), J. Biol. Chem., 273, 5435-5438.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
DnaJ
-
Bos taurus
DnaJ interaction with DnaJ stimulates the hydrolysis of ATP by DnaK Escherichia coli
GrpE
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.31
-
ADP
-
Bos taurus
4.3
-
ATP
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Bos taurus 5737
-
cytosol
-
Bos taurus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Hsp70 activity stimulated by Bos taurus
Mn2+ Hsp70 activity stimulated by Bos taurus
Ni2+ Hsp70 activity stimulated by Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
-
Escherichia coli
70000
-
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + ATP Escherichia coli
-
ATP + ADP
-
r
ADP + ATP Bos taurus
-
ATP + ADP
-
r
ATP + H2O Escherichia coli
-
ADP + phosphate
-
r
ATP + H2O Bos taurus
-
ADP + phosphate
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Escherichia coli
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + ATP
-
Escherichia coli ATP + ADP
-
r
ADP + ATP
-
Bos taurus ATP + ADP
-
r
ATP + H2O
-
Escherichia coli ADP + phosphate
-
r
ATP + H2O
-
Bos taurus ADP + phosphate
-
r
CDP + H2O Hsp70 Bos taurus ?
-
?
dCDP + H2O Hsp70 Bos taurus ?
-
?
dGDP + H2O Hsp70 Bos taurus ?
-
?
dTDP + H2O Hsp70 Bos taurus ?
-
?
GDP + H2O Hsp70 Bos taurus ?
-
?
UDP + H2O Hsp70 Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
Hsc70
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
without ADP Bos taurus
7.5 9 stimulated ATPase in presence of 0.5 mM ADP Bos taurus
7.5 8.5
-
Bos taurus