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Literature summary for 3.6.4.10 extracted from

  • Sadis, S.; Hightower, L.E.
    Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange (1992), Biochemistry, 31, 9406-9412.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
apo c cytosolic precursor of cytochrome c Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0137
-
ATP in absence of apo c Bos taurus
0.0144
-
ATP in presence of apo c Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Saccharomyces cerevisiae 5829
-
cytosol Hsp70 Bos taurus 5829
-
endoplasmic reticulum
-
Saccharomyces cerevisiae 5783
-
endoplasmic reticulum Grp78 Bos taurus 5783
-
mitochondrial matrix Hsp70 Bos taurus 5759
-
nucleus hsc70 Bos taurus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
-
Escherichia coli
70000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Escherichia coli
-
ADP + phosphate
-
?
ATP + H2O Saccharomyces cerevisiae
-
ADP + phosphate
-
?
ATP + H2O Bos taurus
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-
Escherichia coli
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Escherichia coli
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Saccharomyces cerevisiae
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000026
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Escherichia coli ADP + phosphate
-
?
ATP + H2O
-
Saccharomyces cerevisiae ADP + phosphate
-
?
ATP + H2O
-
Bos taurus ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
BiP
-
Bos taurus
DnaK
-
Escherichia coli
eukaryotic Hsc70 ATPase
-
Saccharomyces cerevisiae
eukaryotic Hsc70 ATPase
-
Bos taurus
Grp78
-
Bos taurus
heat shock cognate protein
-
Escherichia coli
heat shock cognate protein
-
Bos taurus
Hsc70
-
Saccharomyces cerevisiae
Hsc70
-
Bos taurus
molecular chaperone GroEl
-
Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0025
-
ATP intrinsic rate Bos taurus
0.00633
-
ATP apo c stimulated rate Bos taurus