Literature summary for 3.6.1.9 extracted from

Laketa, D.; Bjelobaba, I.; Savic, J.; Lavrnja, I.; Stojiljkovic, M.; Rakic, L.; Nedeljkovic, N.
Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum (2010), Mol. Cell. Biochem., 339, 99-106.

Search for more literature for 3.6.1.9

Inhibitors

Inhibitors	Comment	Organism	Structure
2',3'-dialdehyde ATP	competitive inhibition	Rattus norvegicus
2-methylthioadenosine 5'-triphosphate	competitive inhibition	Rattus norvegicus
3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	competitive inhibition	Rattus norvegicus
ADP	competitive inhibition	Rattus norvegicus
alpha,beta-methylene ADP	mixed inhibition	Rattus norvegicus
alpha,beta-methylene ATP	competitive inhibition	Rattus norvegicus
AMP	competitive inhibition	Rattus norvegicus
ATP	competitive inhibition	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0618	-	4-nitrophenyl-5'-TMP	pH and temperature not specified in the publication	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl-5'-TMP + H2O	-	Rattus norvegicus	4-nitrophenol + 5'-TMP	-	?

Synonyms

Synonyms	Comment	Organism
NPP	-	Rattus norvegicus
nucleotide pyrophosphatase/phosphodiesterase	-	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
10.5	-	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	NPP activity is involved in generation, breakdown, and recycling of extracellular adenine nucleotides in the vascular compartment	Rattus norvegicus

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Release 2023.1 (January 2023)