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Literature summary for 3.6.1.9 extracted from

  • Buffon, A.; Casali, E.A.; Cardoso, V.V.; Zerbini, L.F.; Robson, S.C.; Sarkis, J.J.; Wink, M.R.
    Differential expression of nucleotide pyrophosphatase/phosphodiesterases by Walker 256 mammary cancer cells in solid tumors and malignant ascites (2010), Life Sci., 86, 435-440.
    View publication on PubMed
Search for more literature for 3.6.1.9

Inhibitors

Inhibitors Comment Organism Structure
EDTA at 0.5 mM, EDTA greatly reduces the catalytic activity Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information I NPP is not further stimulated by the addition of of crescent concentrations of Ca2+ or Mg2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary cancer cell
-
 Rattus norvegicus
-
Walker-256 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-5'-TMP + H2O
-
 Rattus norvegicus 4-nitrophenol + 5'-TMP
-
 ?

Synonyms

Synonyms Comment Organism
E-NPP
-
 Rattus norvegicus
NPP 1 isoform Rattus norvegicus
NPP 2 isoform Rattus norvegicus
NPP 3 isoform Rattus norvegicus
nucleotide pyrophosphatase/phosphodiesterases
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the mRNA expression in the cells of the ascitic form of Walker 256 tumor reveals transcripts for isoforms NPP2 and NPP3, whereas elevated expression of NPP3 is observed in solid tumor, after 6, 10, and 15 days of inoculation up

General Information

General Information Comment Organism
physiological function isozyme NPP 3 is important for tumor development, once it is more expressed in solid tumor when compared with the ascitic form Rattus norvegicus