Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dimercapto-1-propanol | complete inhibition at 5 mM | Rattus sp. | |
Adenyl-5'-yl imidodiphosphate | 61-78% inhibition at 1 mM | Rattus sp. | |
alpha,beta-methylene adenosine 5'-triphosphate | 61-78% inhibition at 0.3 mM | Rattus sp. | |
CDP-choline | 62% inhibition at 0.2 mM | Rattus sp. | |
coenzyme A | 90% inhibition at 0.2 mM | Rattus sp. | |
EDTA | inactivation after 30 min preincubation at 6 mM | Rattus sp. | |
FAD+ | 79% inhibition at 0.2 mM | Rattus sp. | |
NAD+ | 82% inhibition at 0.2 mM | Rattus sp. | |
p-nitrophenyl 3'-thymidylate | 15% inhibition at 0.2 mM | Rattus sp. | |
p-nitrophenyl 5'-thymidylate | 15% inhibition at 0.2 mM | Rattus sp. | |
thiamine diphosphate | 17% inhibition at 0.2 mM | Rattus sp. | |
UDP-glucose | competitive inhibition of phosphodiesterase activity | Rattus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
GDP-mannose | - |
Rattus sp. | |
0.21 | - |
p-nitrophenyl 5'-TMP | - |
Rattus sp. | |
1.23 | - |
FAD | - |
Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
brush border | - |
Rattus sp. | 5903 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
FAD + H2O | Rattus sp. | - |
FMN + AMP | - |
? | |
GDP-mannose + H2O | Rattus sp. | - |
GMP + D-mannose-1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Rattus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Rattus sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.7 | - |
- |
Rattus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FAD + H2O | - |
Rattus sp. | FMN + AMP | - |
? | |
GDP-mannose + H2O | - |
Rattus sp. | GMP + D-mannose-1-phosphate | - |
? | |
p-nitrophenyl-dTMP + H2O | - |
Rattus sp. | p-nitrophenol + dTMP | - |
? | |
thymidine 5'-monophosphate p-nitrophenyl ester + H2O | - |
Rattus sp. | thymidine 5'-monophosphate + p-nitrophenol | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
65 | - |
half-life: 6.4-10.4 min | Rattus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8.5 | - |
Rattus sp. |