Literature summary for 3.6.1.8 extracted from

Aleixo de Carvalho, L.S.; Geraldo, R.B.; de Moraes, J.; Silva Pinto, P.L.; de Faria Pinto, P.; Pereira, O.d.o.s. .S.; Da Silva Filho, A.A.
Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae) (2015), Exp. Parasitol., 159, 207-214 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
licoflavone B	isolated from Glycyrrhiza inflata, possesses high in vitro schistosomicidal activity against adult worms of Schistosoma mansoni. Licoflavone B causes massive damage in the worm's tegument and inhibits egg laying, without affecting mammalian Vero cells. The tegument of Schistosoma mansoni is crucial for the parasite survival and its host immune defense. Licoflavone B is highly effective in inhibiting Schistosoma mansoni ATP diphosphohydrolase, docking studies with licoflavone B and SmATPase 1 revealing a spontaneous process. The docking study predicts different interactions between licoflavone B and ATPDase 1, corroborating with the in vitro inhibitory activity. Licoflavone B also shows inhibitory activity against ATPase in Schistosoma mansoni	Schistosoma mansoni
additional information	in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots containing echinatin, licoflavone A and licoflavone B	Schistosoma mansoni

Organism

Organism	UniProt	Comment	Textmining
Schistosoma mansoni	Q7YTA4	strain Belo Horizonte, Brazil	-
Schistosoma mansoni BH	Q7YTA4	strain Belo Horizonte, Brazil	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of Schistosoma mansoni. Worms are maintained in Biomphalaria glabrata snails as intermediate hosts and Mesocricetus auratus hamsters as definitive host	Schistosoma mansoni	-

Synonyms

Synonyms	Comment	Organism
ATPDase 1	-	Schistosoma mansoni

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0315	-	pH and temperature not specified in the publication	Schistosoma mansoni	licoflavone B

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Release 2023.1 (January 2023)