Literature summary for 3.6.1.71 extracted from

Tumbale, P.; Jurkiw, T.; Schellenberg, M.; Riccio, A.; O'Brien, P.; Williams, R.
Two-tiered enforcement of high-fidelity DNA ligation (2019), Nat. Commun., 10, 5431 .

Protein Variants

Protein Variants	Comment	Organism
H260N	catalytically inactive	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information	Comment	Organism
physiological function	APTX suppresses DNA-ligase 11-catalyzed ligation of 8oxoG-containing DNA. In presence of APTX, the catalytic commitment of DNA ligase 1 to erroneous ligation is reduced by 70 and 90%, respectively, for the 8oxoG:A and 8oxoG:C substrates	Homo sapiens

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Release 2023.1 (January 2023)