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Literature summary for 3.6.1.71 extracted from
- DNA3pp5G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition (2015), Nucleic Acids Res., 43, 6075-6083.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure in complex with GMP, to 1.5 A resolution. GMP binds at the same position and in the same anti nucleoside conformation as AMP, and aprataxin makes more extensive nucleobase contacts with guanine than with adenine, via a hydrogen bonding network to the guanine O6, N1, N2 base edge | Schizosaccharomyces pombe |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizosaccharomyces pombe | O74859 | - |
- |
| Schizosaccharomyces pombe ATCC 24843 | O74859 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | aprataxin additionally is a DNA 3'-de-capping enzyme, converting DNAppG to DNA3'p and GMP, reaction of EC 3.1.12.2. Aprataxin hydrolyzes inosine and 6-O-methylguanosine caps, but not adeoxyguanosine cap | Schizosaccharomyces pombe | ? | - |
? |  |
| additional information | aprataxin additionally is a DNA 3'-de-capping enzyme, converting DNAppG to DNA3'p and GMP, reaction of EC 3.1.12.2. Aprataxin hydrolyzes inosine and 6-O-methylguanosine caps, but not adeoxyguanosine cap | Schizosaccharomyces pombe ATCC 24843 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aprataxin | - |
Schizosaccharomyces pombe |
| HNT3 | - |
Schizosaccharomyces pombe |
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Release 2023.1 (January 2023)
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