Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | isoforms carrying a 42-nt N-terminal mitochondrial targeting sequence are localized to mitochondria | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7Z2E3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
myoblast | primary skeletal muscle myoblast | Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, SDS-PAGE | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | depletion of aprataxin in human SHSY5Y neuroblastoma cells and primary skeletal muscle myoblasts results in mitochondrial dysfunction, revealed by reduced citrate synthase activity and mtDNA copy number. mtDNA, not nuclear DNA, has higher levels of background DNA damage on aprataxin knockdown | Homo sapiens |