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Literature summary for 3.6.1.70 extracted from

  • Harris, J.L.; Jakob, B.; Taucher-Scholz, G.; Dianov, G.L.; Becherel, O.J.; Lavin, M.F.
    Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage (2009), Hum. Mol. Genet., 18, 4102-4117.
    View publication on PubMed

Application

Application Comment Organism
medicine cells from patients with ataxia oculomotor apraxia AOA1 show reduced expression of poly-ADP ribose polymerase PARP-1, apurinic endonuclease APE1 and N-glycosylase/DNA lyase OGG1. AOA1 cells exhibit elevated levels of oxidative DNA damage coupled with reduced base excision and gap filling repair efficiencies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7Z2E3
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General Information

General Information Comment Organism
physiological function poly-ADP ribose polymerase PARP-1 is required in the recruitment of aprataxin to sites of DNA breaks. Inhibition of PARP activity does not affect aprataxin activity in vitro, it retards its recruitment to sites of DNA damage in vivo Homo sapiens