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Literature summary for 3.6.1.69 extracted from

  • Patil, A.G.; Sang, P.B.; Govindan, A.; Varshney, U.
    Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance (2013), J. Biol. Chem., 288, 11252-11262 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.69

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 8-oxo-dGTP pH 8.0, 37°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Mycobacterium tuberculosis
-
 8-oxo-dGDP + phosphate
-
 ?
8-oxo-dGTP + H2O Mycobacterium tuberculosis H37Rv
-
 8-oxo-dGDP + phosphate
-
 ?
8-oxo-GTP + H2O Mycobacterium tuberculosis
-
 8-oxo-GDP + phosphate
-
 ?
8-oxo-GTP + H2O Mycobacterium tuberculosis H37Rv
-
 8-oxo-GDP + phosphate
-
 ?
additional information Mycobacterium tuberculosis no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP ?
-
 ?
additional information Mycobacterium tuberculosis H37Rv no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WIY3
-
-
Mycobacterium tuberculosis H37Rv P9WIY3
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O
-
 Mycobacterium tuberculosis 8-oxo-dGDP + phosphate
-
 ?
8-oxo-dGTP + H2O
-
 Mycobacterium tuberculosis H37Rv 8-oxo-dGDP + phosphate
-
 ?
8-oxo-GTP + H2O
-
 Mycobacterium tuberculosis 8-oxo-GDP + phosphate
-
 ?
8-oxo-GTP + H2O
-
 Mycobacterium tuberculosis H37Rv 8-oxo-GDP + phosphate
-
 ?
additional information no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP Mycobacterium tuberculosis ?
-
 ?
additional information no substrates: dGTP, GTP, dATP, ATP, dCTP, CTP, 8-oxo-dATP Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

Synonyms Comment Organism
mutT1
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function MutT1 converts 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP. Rv1700 then converts them to the corresponding nucleoside monophosphates. An Escherichia coli strain expressing both MutT1 and Rv100 is rescued during treatment with 2 mM H2O2 Mycobacterium tuberculosis