Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.66 extracted from

  • Yoneshima, Y.; Abolhassani, N.; Iyama, T.; Sakumi, K.; Shiomi, N.; Mori, M.; Shiomi, T.; Noda, T.; Tsuchimoto, D.; Nakabeppu, Y.
    Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells (2016), Sci. Rep., 6, 32849 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.66

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dITP + H2O Mus musculus
-
 dIMP + diphosphate
-
 ?
dITP + H2O Homo sapiens
-
 dIMP + diphosphate
-
 ?
ITP + H2O Mus musculus
-
 IMP + diphosphate
-
 ?
ITP + H2O Homo sapiens
-
 IMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
GM01617 cell
-
 Homo sapiens
-
H-414 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
IMR-90 cell
-
 Homo sapiens
-
MEF cell
-
 Mus musculus
-
WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dITP + H2O
-
 Mus musculus dIMP + diphosphate
-
 ?
dITP + H2O
-
 Homo sapiens dIMP + diphosphate
-
 ?
ITP + H2O
-
 Mus musculus IMP + diphosphate
-
 ?
ITP + H2O
-
 Homo sapiens IMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 20000, SDS-PAGE Mus musculus
? x * 20000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
inosine triphosphatase
-
 Mus musculus
inosine triphosphatase
-
 Homo sapiens
ITPA
-
 Mus musculus
ITPA
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deficiency results in cell growth suppression and DNA instability. Both growth suppression and accumulation of single-strand breaks in nuclear DNA of enzyme-deficient cells depended on MLH1/PMS2 Mus musculus
malfunction enzyme deficiency results in cell growth suppression and DNA instability. Both growth suppression and accumulation of single-strand breaks in nuclear DNA of enzyme-deficient cells depended on MLH1/PMS2 Homo sapiens