Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.062 | - |
IDP | pH 7.5, 37°C | Homo sapiens | |
0.088 | - |
dIDP | pH 7.5, 37°C | Homo sapiens | |
0.32 | - |
dGDP | pH 7.5, 37°C | Homo sapiens | |
0.33 | - |
GDP | pH 7.5, 37°C | Homo sapiens | |
15.7 | - |
XDP | pH 7.5, 37°C | Homo sapiens | |
22.1 | - |
ITP | pH 7.5, 37°C | Homo sapiens | |
24.1 | - |
dITP | pH 7.5, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleolus | - |
Homo sapiens | 5730 | - |
nucleolus | - |
Mus musculus | 5730 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | maximum activity at 1 mM | Homo sapiens | |
additional information | divalent cation absolutely required. No IDP hydrolysis in the presence of 5mM Mn2+, Co2+ or Ca2+ | Homo sapiens | |
Zn2+ | may partly substitue for Mn2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q96DE0 | bifunctional U8 snoRNA-decapping enzyme and IDP phosphatase | - |
Mus musculus | Q6P3D0 | bifunctional U8 snoRNA-decapping enzyme and IDP phosphatase | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dIDP + H2O = dIMP + phosphate | (2) | Homo sapiens | |
IDP + H2O = IMP + phosphate | (1) | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | and lung, highest expression | Homo sapiens | - |
lung | and kidney, highest expression | Homo sapiens | - |
additional information | expression in all tissues examined | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dGDP + H2O | - |
Homo sapiens | dGMP + phosphate | - |
? | |
dIDP + H2O | - |
Homo sapiens | dIMP + phosphate | - |
? | |
dITP + H2O | - |
Mus musculus | dIMP + diphosphate | - |
? | |
dITP + H2O | - |
Homo sapiens | dIMP + diphosphate | hydrolysis of ITP generates IMP but not phosphate | ? | |
GDP + H2O | - |
Homo sapiens | GMP + phosphate | - |
? | |
IDP + H2O | - |
Homo sapiens | IMP + phosphate | - |
? | |
IDP + H2O | - |
Mus musculus | IMP + phosphate | - |
? | |
ITP + H2O | - |
Homo sapiens | IDP + phosphate | - |
? | |
XDP + H2O | - |
Homo sapiens | XMP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
(deoxy)inosine diphosphatase | - |
Homo sapiens |
NUD16 | - |
Homo sapiens |
NUD16 | - |
Mus musculus |
Nudt16 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
temperature-dependent increase in IDP hydrolyzing activity up to 60°C | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
dGDP | pH 7.5, 37°C | Homo sapiens | |
0.009 | - |
GDP | pH 7.5, 37°C | Homo sapiens | |
0.016 | - |
IDP | pH 7.5, 37°C | Homo sapiens | |
0.016 | - |
dIDP | pH 7.5, 37°C | Homo sapiens | |
0.043 | - |
XDP | pH 7.5, 37°C | Homo sapiens | |
0.051 | - |
ITP | pH 7.5, 37°C | Homo sapiens | |
0.053 | - |
dITP | pH 7.5, 37°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown in HeLa MR cells causes cell cycle arrest in S-phase, reduces cell proliferation, and leads to increased accumulation of single-strand breaks in nuclear DNA as well as increased levels of inosine in RNA | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0022 | - |
dITP | pH 7.5, 37°C | Homo sapiens | |
0.0023 | - |
ITP | pH 7.5, 37°C | Homo sapiens | |
0.0027 | - |
XDP | pH 7.5, 37°C | Homo sapiens | |
0.0257 | - |
dGDP | pH 7.5, 37°C | Homo sapiens | |
0.0261 | - |
GDP | pH 7.5, 37°C | Homo sapiens | |
0.183 | - |
dIDP | pH 7.5, 37°C | Homo sapiens | |
0.251 | - |
IDP | pH 7.5, 37°C | Homo sapiens |