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Literature summary for 3.6.1.64 extracted from

  • Iyama, T.; Abolhassani, N.; Tsuchimoto, D.; Nonaka, M.; Nakabeppu, Y.
    NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest (2010), Nucleic Acids Res., 38, 4834-4843.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.062
-
IDP pH 7.5, 37°C Homo sapiens
0.088
-
dIDP pH 7.5, 37°C Homo sapiens
0.32
-
dGDP pH 7.5, 37°C Homo sapiens
0.33
-
GDP pH 7.5, 37°C Homo sapiens
15.7
-
XDP pH 7.5, 37°C Homo sapiens
22.1
-
ITP pH 7.5, 37°C Homo sapiens
24.1
-
dITP pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleolus
-
Homo sapiens 5730
-
nucleolus
-
Mus musculus 5730
-
nucleus
-
Homo sapiens 5634
-
nucleus
-
Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ maximum activity at 1 mM Homo sapiens
additional information divalent cation absolutely required. No IDP hydrolysis in the presence of 5mM Mn2+, Co2+ or Ca2+ Homo sapiens
Zn2+ may partly substitue for Mn2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q96DE0 bifunctional U8 snoRNA-decapping enzyme and IDP phosphatase
-
Mus musculus Q6P3D0 bifunctional U8 snoRNA-decapping enzyme and IDP phosphatase
-

Reaction

Reaction Comment Organism Reaction ID
dIDP + H2O = dIMP + phosphate (2) Homo sapiens
IDP + H2O = IMP + phosphate (1) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney and lung, highest expression Homo sapiens
-
lung and kidney, highest expression Homo sapiens
-
additional information expression in all tissues examined Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dGDP + H2O
-
Homo sapiens dGMP + phosphate
-
?
dIDP + H2O
-
Homo sapiens dIMP + phosphate
-
?
dITP + H2O
-
Mus musculus dIMP + diphosphate
-
?
dITP + H2O
-
Homo sapiens dIMP + diphosphate hydrolysis of ITP generates IMP but not phosphate ?
GDP + H2O
-
Homo sapiens GMP + phosphate
-
?
IDP + H2O
-
Homo sapiens IMP + phosphate
-
?
IDP + H2O
-
Mus musculus IMP + phosphate
-
?
ITP + H2O
-
Homo sapiens IDP + phosphate
-
?
XDP + H2O
-
Homo sapiens XMP + phosphate
-
?

Synonyms

Synonyms Comment Organism
(deoxy)inosine diphosphatase
-
Homo sapiens
NUD16
-
Homo sapiens
NUD16
-
Mus musculus
Nudt16
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
temperature-dependent increase in IDP hydrolyzing activity up to 60°C Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.008
-
dGDP pH 7.5, 37°C Homo sapiens
0.009
-
GDP pH 7.5, 37°C Homo sapiens
0.016
-
IDP pH 7.5, 37°C Homo sapiens
0.016
-
dIDP pH 7.5, 37°C Homo sapiens
0.043
-
XDP pH 7.5, 37°C Homo sapiens
0.051
-
ITP pH 7.5, 37°C Homo sapiens
0.053
-
dITP pH 7.5, 37°C Homo sapiens

General Information

General Information Comment Organism
physiological function knockdown in HeLa MR cells causes cell cycle arrest in S-phase, reduces cell proliferation, and leads to increased accumulation of single-strand breaks in nuclear DNA as well as increased levels of inosine in RNA Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0022
-
dITP pH 7.5, 37°C Homo sapiens
0.0023
-
ITP pH 7.5, 37°C Homo sapiens
0.0027
-
XDP pH 7.5, 37°C Homo sapiens
0.0257
-
dGDP pH 7.5, 37°C Homo sapiens
0.0261
-
GDP pH 7.5, 37°C Homo sapiens
0.183
-
dIDP pH 7.5, 37°C Homo sapiens
0.251
-
IDP pH 7.5, 37°C Homo sapiens