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Literature summary for 3.6.1.6 extracted from

  • Sano, S.; Matsuda, Y.; Miyamoto, S.; Nakagawa, H.
    Thiamine pyrophosphatase and nucleoside diphosphatase in rat brain (1984), Biochem. Biophys. Res. Commun., 118, 292-298.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP 0.2 mM, 2fold increase of activity with IDP, 10fold increase of activity with TPP, type L enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
AMP 0.07 mM, , 50% inhibition, type B enzyme Rattus norvegicus
ATP
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
enzyme form B, gel filtration Rattus norvegicus
140000
-
type L enzyme, gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain enzyme type L and enzyme type B Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP + H2O 43% of the activity with IDP, enzyme type B. 8% of the activity with IDP, enzyme type L Rattus norvegicus CMP + phosphate
-
?
dTDP + H2O 14% of the activity with IDP, type L enzyme Rattus norvegicus dTMP + phosphate
-
?
GDP + H2O 95% of the activity with IDP, enzyme type B and enzyme type L Rattus norvegicus GMP + phosphate
-
?
IDP + H2O
-
Rattus norvegicus IMP + phosphate
-
?
TPP + H2O 64% of the activity with IDP, enzyme type B. 4% of the activity with IDP, enzyme type L Rattus norvegicus thiamine phosphate + phosphate
-
?
UDP + H2O 59% of activity with IDP, enzyme type B. 88% of the activity with IDP, enzyme type L Rattus norvegicus UMP + phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
hydrolysis of IDP and TPP, enzyme type B Rattus norvegicus
6.5
-
hydrolysis of IDP, enzyme type L Rattus norvegicus
9
-
TPPase activity, enzyme type L Rattus norvegicus