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Literature summary for 3.6.1.59 extracted from

  • Liu, S.W.; Rajagopal, V.; Patel, S.S.; Kiledjian, M.
    Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme (2008), J. Biol. Chem., 283, 16427-16436.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information DcpS exhibits different enzymatic kinetics under low and high substrate conditions, negative cooperativity between two wild type subunits, reduced decapping activity is displayed by the DcpSWT/HIT heterodimer under high substrate conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
m7G5'ppp5'N(3'ppp5'N)n + H2O Homo sapiens n = 1-8, decapping is an important process in the control of eukaryotic mRNA degradation. The scavenger decapping enzyme DcpS functions to clear the cell of cap structure following decay of the RNA body by catalyzing the hydrolysis of m7GpppN to m7Gp and ppN 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96C86
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8 Homo sapiens 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
-
 ?
m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8, decapping is an important process in the control of eukaryotic mRNA degradation. The scavenger decapping enzyme DcpS functions to clear the cell of cap structure following decay of the RNA body by catalyzing the hydrolysis of m7GpppN to m7Gp and ppN Homo sapiens 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens