Literature summary for 3.6.1.58 extracted from

Ito, R.; Sekiguchi, M.; Setoyama, D.; Nakatsu, Y.; Yamagata, Y.; Hayakawa, H.
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein (2011), J. Biochem., 149, 731-738.

Search for more literature for 3.6.1.58

Inhibitors

Inhibitors	Comment	Organism	Structure
8-oxo-dGDP	inhibits cleavage of ADP-ribose	Homo sapiens
ADP-ribose	inhibits cleavage of 8-oxo-dGTP	Homo sapiens
AMP	inhibits cleavage of 8-oxo-dGTP	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0035	-	8-oxo-dGDP	pH 10.0, 30°C	Homo sapiens
0.0038	-	8-oxo-dGDP	pH 8, 30°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
8-oxo-dGDP + H2O	ADP-ribose is a better substrate for NUDT5 compared with oxidized guanine nucleotides	Homo sapiens	8-oxo-dGMP + phosphate	-	?
additional information	the bifunctional enzyme also hydrolyses ADP-ribose to ADP-ribose and ribose 5-phosphate (cf. EC 3.6.1.13)	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
NUDT5	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	hydrolysis of 8-oxo-dGDP, assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
10	-	cleavage of 8-oxo-dGDP	Homo sapiens

pH Range

pH Minimum	pH Maximum	Comment	Organism
9.5	12	pH 9.5: about 50% of maximal activity, pH 12.0: about 50% of maximal activity	Homo sapiens

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Release 2023.1 (January 2023)