Literature summary for 3.6.1.58 extracted from

Hori, M.; Satou, K.; Harashima, H.; Kamiya, H.
Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5 (2010), Free Radic. Biol. Med., 48, 1197-1201.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UKK9	-	-

Synonyms

Synonyms	Comment	Organism
NUDT5	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	the knockdown of the MTH1, MTH2, and NUDT5 proteins increases the A:T to C:G substitution mutations induced by 8-hydroxy-dGTP. In addition, the increase in the induced mutation frequency is more evident in the triple-knockdown cells	Homo sapiens
physiological function	all three of the human MTH1, MTH2, and NUDT5 proteins act as a defense against the mutagenesis induced by oxidized dGTP	Homo sapiens

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Release 2023.1 (January 2023)