KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
8-oxo-dGDP | pH 8.0, 30°C | Homo sapiens | |
0.0029 | - |
8-oxo-dADP | pH 8.0, 30°C | Homo sapiens | |
0.004 | - |
5-formyl-dUDP | pH 8.0, 30°C | Homo sapiens | |
0.0076 | - |
dGDP | pH 8.0, 30°C | Homo sapiens | |
0.0088 | - |
2-hydroxy-dADP | pH 8.0, 30°C | Homo sapiens | |
0.0126 | - |
dADP | pH 8.0, 30°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UKK9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxy-dADP + H2O | kcat/KM is 15% of the wild-type value | Homo sapiens | 2-hydroxy-dAMP + phosphate | - |
? | |
5-formyl-dUDP + H2O | kcat/KM is 30% of the wild-type value | Homo sapiens | 5-formyl-dUMP + phosphate | - |
? | |
8-oxo-dADP + H2O | 8-oxo-dADP is hydrolyzed slightly more efficiently than 8-oxo-dGDP | Homo sapiens | 8-oxo-dAMP + phosphate | - |
? | |
8-oxo-dGDP + H2O | NUDT5 protein is a hydrolyzing enzyme with broad substrate specificity for oxidized deoxyribonucleoside diphosphates | Homo sapiens | 8-oxo-dGMP + phosphate | - |
? | |
dADP + H2O | kcat/KM is 16% of the wild-type value | Homo sapiens | dAMP + phosphate | - |
? | |
dGDP + H2O | - |
Homo sapiens | dGMP + phosphate | - |
? | |
additional information | the hydrolyses of 2-hydroxy-dADP and 5-formyl-dUDP are less effective, with 0.4- and 0.5-fold efficiencies relative to that of 8-oxo-dGDP, respectively. The hydrolyses of the triphosphate derivatives are less efficient than those of the diphosphate counterparts | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NUDT5 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
5-formyl-dUDP | pH 8.0, 30°C | Homo sapiens | |
0.004 | - |
2-hydroxy-dADP | pH 8.0, 30°C | Homo sapiens | |
0.006 | - |
dADP | pH 8.0, 30°C | Homo sapiens | |
0.006 | - |
8-oxo-dGDP | pH 8.0, 30°C | Homo sapiens | |
0.009 | - |
8-oxo-dADP | pH 8.0, 30°C | Homo sapiens | |
0.015 | - |
dGDP | pH 8.0, 30°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.45 | - |
2-hydroxy-dADP | pH 8.0, 30°C | Homo sapiens | |
0.48 | - |
dADP | pH 8.0, 30°C | Homo sapiens | |
0.88 | - |
5-formyl-dUDP | pH 8.0, 30°C | Homo sapiens | |
2.9 | - |
8-oxo-dGDP | pH 8.0, 30°C | Homo sapiens | |
3.1 | - |
8-oxo-dADP | pH 8.0, 30°C | Homo sapiens |