Protein Variants | Comment | Organism |
---|---|---|
D119A | mutant enzyme shows no hydrolytic activity with 2-hydroxy-dATP. Specific activity with 8-oco-dGTP is 139% of wild-type activity | Homo sapiens |
W117Y | mutant enzyme shows hydrolytic acitivity with 8-oxo-dGTP. Specific activity with 2-hydroxy-dATP is 86% of wild-type activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxy-dATP + H2O | Homo sapiens | MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP. These alterations may be partly attributed to a mitochondrial dysfunction | 2-hydroxy-dAMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P36639 | - |
- |
Mus musculus | P53368 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxy-dATP + H2O | - |
Homo sapiens | 2-hydroxy-dAMP + diphosphate | - |
? | |
2-hydroxy-dATP + H2O | MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP. These alterations may be partly attributed to a mitochondrial dysfunction | Homo sapiens | 2-hydroxy-dAMP + diphosphate | - |
? | |
8-oxo-dGTP + H2O | this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | Homo sapiens | 8-oxo-dGMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MTH1 | - |
Mus musculus |
MTH1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | MTH1 protects the dopamine neurons from oxidative damage in the nucleic acids, especially in the mitochondrial DNA of striatal nerve terminals of dopamine neurons | Mus musculus |