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Literature summary for 3.6.1.55 extracted from
- Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2 (2012), J. Biol. Chem., 287, 21541-21549.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21 cells | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0117 | - |
8-oxo-GDP | in Tris-HCl buffer (pH 8.0), at 37°C | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P36639 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| HisTrap column chromatography, HiTrap heparin column chromatography, and Mono S column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8-oxo-dGTP + H2O | - |
Homo sapiens | 8-oxo-dGMP + diphosphate | - |
? | |
| 8-oxo-GDP + H2O | - |
Homo sapiens | 8-oxo-GMP + phosphate | - |
? | |
| additional information | the enzyme does not cleave 8-oxo-dGDP | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MTH1 | - |
Homo sapiens |
| MutT homologue 1 | - |
Homo sapiens |
| NUDT1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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