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Literature summary for 3.6.1.55 extracted from

  • Maki, H.; Sekiguchi, M.
    MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis (1992), Nature, 355, 273-275.
    View publication on PubMed
Search for more literature for 3.6.1.55

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.48
-
 8-oxo-dGTP pH and temperature not specified in the publication Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Escherichia coli prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis 8-oxo-dGMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis Escherichia coli 8-oxo-dGMP + diphosphate
-
 ?
8-oxo-dGTP + H2O specfic for the MutT protein hydrolyses other dNTPs and GTP with lower Vmax and extremely high Km-values Escherichia coli 8-oxo-dGMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
MutT
-
 Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis Escherichia coli