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Literature summary for 3.6.1.55 extracted from

  • Nakamura, T.; Meshitsuka, S.; Kitagawa, S.; Abe, N.; Yamada, J.; Ishino, T.; Nakano, H.; Tsuzuki, T.; Doi, T.; Kobayashi, Y.; Fujii, S.; Sekiguchi, M.; Yamagata, Y.
    Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base (2010), J. Biol. Chem., 285, 444-452.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structures of MutT in the apo and holo forms and in the binary and ternary forms complexed with the product 8-oxo-dGMP and 8-oxo-dGMP plus Mn2+, respectively, are determined Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Escherichia coli the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA 8-oxo-dGMP + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P08337
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA Escherichia coli 8-oxo-dGMP + diphosphate
-
 ?
8-oxo-dGTP + H2O MutT exhibits high substrate specificity for 8-oxoguanine nucleotides by the ligand-induced conformational change Escherichia coli 8-oxo-dGMP + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
MutT
-
 Escherichia coli